李思思 | 李思思实验室

Morphological Programming in Gold (III) Coordination Assemblies via pH-Modulated Noncovalent Hierarchy

Thu, 01 Jan 2026 00:00:00 +0000

李思思

Thu, 01 Jan 2026 00:00:00 +0000

李思思博士是深圳大学医学部国际肿瘤中心教授、博士生导师。她在复旦大学获得博士学位，并在纽约纪念斯隆-凯特琳癌症中心完成博士后训练。

李博士入选国家级青年人才项目（B类）、深圳市杰出青年基金获得者及深圳市海外高层次人才。她目前担任深圳市欧美同学会理事，以及中国生物化学与分子生物学会基础医学分会委员。

研究方向

她的实验室致力于研究RNA稳态调节的分子机制。结合生物化学、分子生物学和细胞生物学，课题组建立了一个涵盖以下内容的综合研究框架：

调节性RNA的化学和结构分析
阐明控制转录本稳定性和功能的RNA-蛋白质调节机制
在发育和疾病中的体内生理功能验证
探索RNA靶向治疗策略，特别关注免疫相关疾病

发表成果与学术认可

在过去五年中，李博士作为第一作者或通讯作者（含共同通讯）在 Science, Nature Communications, Nature Chemical Biology, PNAS, 和 Molecular Plant 等期刊上发表了十余篇论文。她的多项研究获得了专题评论和学术媒体的报道。她担任多个国际知名期刊的审稿人，并主持了多项来自国家自然科学基金（NSFC）、深圳市科技创新委员会等机构的国家级和省部级科研项目。

资助项目

国家自然科学基金面上项目 (32471253), 2025–2028
深圳市医学研究专项资金 (B2402026), 2025–2027
深圳市杰出青年基础研究项目 (RCJC20231211085924032), 2024–2029
国家自然科学基金优秀青年科学基金 (32222039), 2023–2025
国家自然科学基金面上项目 (31870755), 2019–2022

Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice

Wed, 01 Jan 2025 00:00:00 +0000

Long noncoding RNA ARTA controls ABA response through MYB7 nuclear trafficking in Arabidopsis

Sun, 01 Jan 2023 00:00:00 +0000

Molecular basis of the plant ROS1-mediated active DNA demethylation

Sun, 01 Jan 2023 00:00:00 +0000

Structure and mechanism of the plant RNA polymerase V

Sun, 01 Jan 2023 00:00:00 +0000

Making a 6mA demethylase

Sat, 01 Jan 2022 00:00:00 +0000

Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production

Sat, 01 Jan 2022 00:00:00 +0000

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

Fri, 01 Jan 2021 00:00:00 +0000

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis

Fri, 01 Jan 2021 00:00:00 +0000

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Fri, 01 Jan 2021 00:00:00 +0000

Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex

Fri, 01 Jan 2021 00:00:00 +0000

TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis

Fri, 01 Jan 2021 00:00:00 +0000

Dual recognition of H3K4me3 and DNA by the ISWI component ARID5 regulates the floral transition in Arabidopsis

Wed, 01 Jan 2020 00:00:00 +0000

Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing

Tue, 01 Jan 2019 00:00:00 +0000

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Tue, 01 Jan 2019 00:00:00 +0000

Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation

Mon, 01 Jan 2018 00:00:00 +0000

Structure of the Arabidopsis JMJ14-H3K4me3 complex provides insight into the substrate specificity of KDM5 subfamily histone demethylases

Mon, 01 Jan 2018 00:00:00 +0000

Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors