Publications

1. Yelan Xiao , Xiang Zhou , Nuo Cheng , Jianxin Ma , Jiacheng Yang , Jiarong Tian , Guolei Gao , Zhen Zhang , Mu-Peng Luo , Shou-Guo Wang , Sisi Li , Tong Shu , Xueji Zhang Morphological Programming in Gold (III) Coordination Assemblies via pH-Modulated Noncovalent Hierarchy. ACS Applied Materials & Interfaces, 18(19), 27946-27956 (2026).

2. Xuefei Wang , Meng Dong , Xinchao Wu , Daniel Schnepf , Julia Thiel , Wenfei Sun , Christian Wolfrum , Sisi Li , Wenfei Jin , Peter Staeheli Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice. Journal of Virology, 99(3), e01413-24 (2025).

3. Guohui Xie , Xuan Du , Hongmiao Hu , Sisi Li , Xiaofeng Cao , Steven E Jacobsen , Jiamu Du Structure and mechanism of the plant RNA polymerase V. Science, 379(6638), 1209-1213 (2023).

4. Xuan Du , Zhenlin Yang , Guohui Xie , Changshi Wang , Laixing Zhang , Kaige Yan , Maojun Yang , Sisi Li , Jian-Kang Zhu , Jiamu Du Molecular basis of the plant ROS1-mediated active DNA demethylation. Nature Plants, 9(2), 271-279 (2023).

5. Jun Yang , Reqing He , Zhipeng Qu , Jinbao Gu , Liyun Jiang , Xiangqiang Zhan , Ying Gao , David L Adelson , Sisi Li , Zhen-Yu Wang , Youlin Zhu , Dong Wang Long noncoding RNA ARTA controls ABA response through MYB7 nuclear trafficking in Arabidopsis. Developmental Cell, 58(13), 1206-1217 (2023).

6. Xuan Du , Zhenlin Yang , Alfredo Jose Florez Ariza , Qian Wang , Guohui Xie , Sisi Li , Jiamu Du Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production. The Plant Cell, 34(6), 2140-2149 (2022).

7. Sisi Li , Jiamu Du Making a 6mA demethylase. Nature Chemical Biology, 18(7), 683-684 (2022).

8. Qian Wang , Yan Xue , Laixing Zhang , Zhenhui Zhong , Suhua Feng , Changshi Wang , Lifan Xiao , Zhenlin Yang , C Jake Harris , Zhe Wu , Jixian Zhai , Maojun Yang , Sisi Li , Steven E Jacobsen , Jiamu Du A SYBR gold-based label-free in vitro dicing assay. Bio-protocol, 12(7), e4382-e4382 (2022).

9. Hongmiao Hu , Shu Tian , Guohui Xie , Rui Liu , Nana Wang , Sisi Li , Yuehui He , Jiamu Du TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis. Proceedings of the National Academy of Sciences, 118(35), e2103895118 (2021).

10. Sisi Li , Tian Xie , Peng Liu , Lei Wang , Xin Gong Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex. Nature structural & molecular biology, 28(3), 249-257 (2021).

11. Wanqiu Li , Linlin Wang , Bradley M Wierbowski , Mo Lu , Feitong Dong , Wenchen Liu , Sisi Li , Peiyi Wang , Adrian Salic , Xin Gong Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release. Nature Communications, 12(1), 6966 (2021).

12. Qian Wang , Yan Xue , Laixing Zhang , Zhenhui Zhong , Suhua Feng , Changshi Wang , Lifan Xiao , Zhenlin Yang , C Jake Harris , Zhe Wu , Jixian Zhai , Maojun Yang , Sisi Li , Steven E Jacobsen , Jiamu Du Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation. Science, 374(6571), 1152-1157 (2021).

13. Yifeng Hou , Jing Sun , Baixing Wu , Yangyang Gao , Hongbo Nie , Zhentian Nie , Shuxuan Quan , Yong Wang , Xiaofeng Cao , Sisi Li CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis. Molecular plant, 14(4), 688-699 (2021).

14. Xiawei Huang , Hongmiao Hu , Alexandre Webster , Fan Zou , Jiamu Du , Dinshaw J Patel , Ravi Sachidanandam , Katalin Fejes Toth , Alexei a Aravin , Sisi Li Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex. Nature Communications, 12(1), 4061 (2021).

15. Lian-Mei Tan , Rui Liu , Bo-Wen Gu , Cui-Jun Zhang , Jinyan Luo , Jing Guo , Yuhua Wang , Lixian Chen , Xuan Du , Sisi Li Dual recognition of H3K4me3 and DNA by the ISWI component ARID5 regulates the floral transition in Arabidopsis. The Plant Cell, 32(7), 2178-2195 (2020).

16. Fan Zou , Renjun Tu , Bo Duan , Zhenlin Yang , Zhaohua Ping , Xiaoqing Song , Shiyuan Chen , Andrew Price , Hua Li , Allison Scott , Anoja Perera , Sisi Li , Ting Xie Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proceedings of the National Academy of Sciences, 117(7), 3603-3609 (2020).

17. Shuzhi Zheng , Hongmiao Hu , Huimin Ren , Zhenlin Yang , Qi Qiu , Weiwei Qi , Xinye Liu , Xiaomei Chen , Xiekui Cui , Sisi Li The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor. Nature communications, 10(1), 1303 (2019).

18. Baixing Wu , Dong Zhang , Hongbo Nie , Senlin Shen , Yan Li , Sisi Li Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing. RNA biology, 16(10), 1504-1512 (2019).

19. Zhenlin Yang , Qi Qiu , Wei Chen , Bei Jia , Xiaomei Chen , Hongmiao Hu , Kaixuan He , Xian Deng , Sisi Li , W Andy Tao Structure of the Arabidopsis JMJ14-H3K4me3 complex provides insight into the substrate specificity of KDM5 subfamily histone demethylases. The Plant Cell, 30(1), 167-177 (2018).

20. Xueqin Li , C Jake Harris , Zhenhui Zhong , Wei Chen , Rui Liu , Bei Jia , Zonghua Wang , Sisi Li , Steven E Jacobsen , Jiamu Du Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation. Proceedings of the National Academy of Sciences, 115(37), E8793-E8802 (2018).

21. Xiaojie Shi , Zihan Ran , Sisi Li , Juan Yin , Jiang Zhong The effect of MicroRNA bantam on baculovirus AcMNPV infection in vitro and in vivo. Viruses, 8(5), 136 (2016).

22. Katharina Höfer , Sisi Li , Florian Abele , Jens Frindert , Jasmin Schlotthauer , Julia Grawenhoff , Jiamu Du , Dinshaw J Patel , Andres Jäschke Structure and function of the bacterial decapping enzyme NudC. Nature chemical biology, 12(9), 730-734 (2016).

23. Sisi Li , Zhenlin Yang , Xuan Du , Rui Liu , Alex W Wilkinson , Or Gozani , Steven E Jacobsen , Dinshaw J Patel , Jiamu Du Structural basis for the unique multivalent readout of unmodified H3 tail by Arabidopsis ORC1b BAH-PHD cassette. Structure, 24(3), 486-494 (2016).

24. Sisi Li , Linda Yen , William a Pastor , Jonathan B Johnston , Jiamu Du , Colin J Shew , Wanlu Liu , Jamie Ho , Bryan Stender , Amander T Clark , Alma L Burlingame , Lucia Daxinger , Dinshaw J Patel , Steven E Jacobsen Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Proceedings of the National Academy of Sciences, 113(35), E5108-E5116 (2016).

25. Sisi Li , Dinshaw J Patel Drosha and Dicer: Slicers cut from the same cloth. Cell research, 26(5), 511-512 (2016).

26. Yung-Chia Ariel Chen , Evelyn Stuwe , Yicheng Luo , Maria Ninova , Adrien Le Thomas , Ekaterina Rozhavskaya , Sisi Li , Sivani Vempati , John D Laver , Dinshaw J Patel Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors. Molecular cell, 63(1), 97-109 (2016).

27. Boseon Kim , Minju Ha , Luuk Loeff , Hyeshik Chang , Dhirendra K Simanshu , Sisi Li , Mohamed Fareh , Dinshaw J Patel , Chirlmin Joo , V Narry Kim TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms. The EMBO journal, 34(13), 1801-1815 (2015).

28. Alexandre Webster , Sisi Li , Junho K Hur , Malte Wachsmuth , Justin S Bois , Edward M Perkins , Dinshaw J Patel , Alexei a Aravin Aub and Ago3 are recruited to nuage through two mechanisms to form a ping-pong complex assembled by Krimper. Molecular cell, 59(4), 564-575 (2015).

29. Adrien Le Thomas , Evelyn Stuwe , Sisi Li , Jiamu Du , Georgi Marinov , Nikolay Rozhkov , Yung-Chia Ariel Chen , Yicheng Luo , Ravi Sachidanandam , Katalin Fejes Toth Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes & development, 28(15), 1667-1680 (2014).

30. Jiamu Du , Lianna M Johnson , Martin Groth , Suhua Feng , Christopher J Hale , Sisi Li , Ajay a Vashisht , Javier Gallego-Bartolome , James a Wohlschlegel , Dinshaw J Patel Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Molecular cell, 55(3), 495-504 (2014).

31. Binbin Li , Sisi Li , Juan Yin , Jiang Zhong Identification and characterization of the Spodoptera Su (var) 3-9 histone H3K9 trimethyltransferase and its effect in AcMNPV infection. PLoS One, 8(7), e69442 (2013).

32. Sisi Li , Jiamu Du , Hui Yang , Juan Yin , Jianping Ding , Jiang Zhong Functional and structural characterization of DNMT2 from Spodoptera frugiperda. Journal of molecular cell biology, 5(1), 64-66 (2013).