Sisi Li | Sisi Li Lab

Morphological Programming in Gold (III) Coordination Assemblies via pH-Modulated Noncovalent Hierarchy

Thu, 01 Jan 2026 00:00:00 +0000

Sisi Li

Thu, 01 Jan 2026 00:00:00 +0000

Dr. Sisi Li is a Professor at the International Cancer Center, Medical School, Shenzhen University, where she serves as a doctoral supervisor. She received her PhD from Fudan University and completed her postdoctoral training at Memorial Sloan Kettering Cancer Center in New York.

Dr. Li is a recipient of the National Young Talent Program (Category B), the Shenzhen Outstanding Youth Foundation, and the Shenzhen Overseas High-Level Talent designation. She currently serves as a council member of the Shenzhen Federation of Western-Returned Scholars and as a committee member of the Basic Medical Sciences Branch of the Chinese Society of Biochemistry and Molecular Biology.

Research

Her laboratory investigates the molecular mechanisms underlying RNA homeostasis regulation. Integrating biochemistry, molecular biology, and cell biology, the group has established a comprehensive research framework that spans:

Chemical and structural analysis of regulatory RNAs
Elucidation of RNA–protein regulatory mechanisms governing transcript stability and function
In vivo validation of physiological roles in development and disease
Exploration of RNA-targeted therapeutic strategies, with a particular focus on immune-related disorders

Publications & Recognition

Over the past five years, Dr. Li has published more than ten papers as first or corresponding author (including co-corresponding) in journals such as Science, Nature Communications, Nature Chemical Biology, PNAS, and Molecular Plant. Several of her studies have been highlighted by accompanying commentaries and featured in academic media. She serves as a reviewer for multiple internationally recognized journals and is the principal investigator of numerous national and provincial research grants from the NSFC, Shenzhen Municipal Science and Technology Innovation Commission, and other agencies.

Selected Funding

NSFC General Program (32471253), 2025–2028
Shenzhen Medical Research Special Fund (B2402026), 2025–2027
Shenzhen Outstanding Youth Basic Research Program (RCJC20231211085924032), 2024–2029
NSFC Excellent Young Scientists Fund (32222039), 2023–2025
NSFC General Program (31870755), 2019–2022

Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice

Wed, 01 Jan 2025 00:00:00 +0000

Long noncoding RNA ARTA controls ABA response through MYB7 nuclear trafficking in Arabidopsis

Sun, 01 Jan 2023 00:00:00 +0000

Molecular basis of the plant ROS1-mediated active DNA demethylation

Sun, 01 Jan 2023 00:00:00 +0000

Structure and mechanism of the plant RNA polymerase V

Sun, 01 Jan 2023 00:00:00 +0000

Making a 6mA demethylase

Sat, 01 Jan 2022 00:00:00 +0000

Structure of plant RNA-DEPENDENT RNA POLYMERASE 2, an enzyme involved in small interfering RNA production

Sat, 01 Jan 2022 00:00:00 +0000

Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

Fri, 01 Jan 2021 00:00:00 +0000

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis

Fri, 01 Jan 2021 00:00:00 +0000

Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release

Fri, 01 Jan 2021 00:00:00 +0000

Structural insights into the assembly and substrate selectivity of human SPT–ORMDL3 complex

Fri, 01 Jan 2021 00:00:00 +0000

TEM1 combinatorially binds to FLOWERING LOCUS T and recruits a Polycomb factor to repress the floral transition in Arabidopsis

Fri, 01 Jan 2021 00:00:00 +0000

Dual recognition of H3K4me3 and DNA by the ISWI component ARID5 regulates the floral transition in Arabidopsis

Wed, 01 Jan 2020 00:00:00 +0000

Structure of Arabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications for N6-methyl-AMP recognition and processing

Tue, 01 Jan 2019 00:00:00 +0000

The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Tue, 01 Jan 2019 00:00:00 +0000

Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation

Mon, 01 Jan 2018 00:00:00 +0000

Structure of the Arabidopsis JMJ14-H3K4me3 complex provides insight into the substrate specificity of KDM5 subfamily histone demethylases

Mon, 01 Jan 2018 00:00:00 +0000

Cutoff suppresses RNA polymerase II termination to ensure expression of piRNA precursors